Molecular and Phenotypic Evaluation of Lichtheimia corymbifera (Formerly Absidia corymbifera ) Complex Isolates Associated with Human Mucormycosis: Rehabilitation of L. ramosa
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منابع مشابه
Isolation and characterization of a strain of Lichtheimia corymbifera (ex Absidia corymbifera) from a case of bovine abortion
BACKGROUND Lichtheimia corymbifera (previously Absidia corymbifera) is a filamentous zygomycetes belonging to the order Mucorales and to the family Lichtheimiaceae. Members of genus Lichtheimia spp. are cosmopolitan and ubiquitous in nature. Lichtheimia corymbifera is a recognized agent of diseases in man and animals. In cattle it causes abortion and mastitis. Three cases of bovine abortion occ...
متن کاملComparative virulence of Absidia corymbifera strains in mice.
The comparative virulence of six different strains of Absidia corymbifera for cortisone-treated and untreated Swiss mice was determined. Spores of the six strains were inoculated into mice by the intravenous, intraperitoneal, and intranasal routes. All six strains were found to be virulent in cortisone-treated and untreated mice by the intravenous route. Up to a 16-fold difference in strain vir...
متن کاملLichtheimia ramosa: A Fatal Case of Mucormycosis
Mucormycosis due to Lichtheimia ramosa is an infrequent opportunistic infection that can potentially be angioinvasive when affecting inmunocompromised hosts. We present a fatal case of mucormycosis, affecting a 56-year-old male with diabetes mellitus and siderosis, initially admitted to our hospital due to an H1N1 infection. The subject's clinical condition worsened and he finally died because ...
متن کاملSpecies recognition and clinical relevance of the zygomycetous genus Lichtheimia (syn. Absidia pro parte, Mycocladus).
The zygomycete genus Lichtheimia (syn. Absidia pro parte, Mycocladus) consists of saprotrophic fungi inhabiting soil or dead plant material. Lichtheimia corymbifera (syn. Absidia corymbifera, Mycocladus corymbifer) and Lichtheimia ramosa (syn. Absidia ramosa, Mycocladus ramosus) may cause fulminant infections in patients with impaired immunity. The present study investigated the species boundar...
متن کاملMolecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae.
Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2009
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.02094-08